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For PEF morning a baseline numerical effects than patients with large lung is obtained as the mean value over a number volumes purchase 2 mg ginette-35, like tall men buy discount ginette-35 2 mg online. This does not mean of measurements, typically 1–2 weeks, and then that the actual beneﬁt to the patient is less, the effect variable as the mean of 1–3 months only that the outcome variable suffers from of data. Similarly, for by measuring lung function in percent of pre- FEV1 the table refers to a measurement both at baseline and end of treatment, but the treatment dicted normal, which tries to capture size dif- value could well be a mean of a number of ferences, instead. Moreover, the FEV data refers to remedy to a larger problem – that there is a 1 the situation when visits to the clinic are spread large heterogeneity in response sizes for some out over the morning, the European style, as outcome variables, which does not necessarily discussed earlier. Changes is not a problem for the proper conclusions of in symptom scores are often small in studies in a clinical trial. Consider a randomised parallel asthmatics with mild–moderate severity, since group study in which treatments A and B they do not have many symptoms on entry. If properly conducted observed rhinitis studies a combination of symptom scores treatment differences should be explained by is often done. If we use the TNS discussed earlier different treatment effects alone, and any claim we typically have a standard deviation of about from the study should relate to the relative 1. Typically, therefore, rhinitis studies can be that the effects differ, say, between men and smaller than asthma studies. A rate of one exac- that the sex distribution is similar in the two erbation per year can be used in sample size groups. Differences in effect sizes could well be explained not only SUBGROUP ANALYSIS by different patient populations, including gender When doing statistics on trials in respiratory distribution, but also by different compliance to medicine, the question of subgroup analysis study procedures in the trials. It is often EFFICACY STUDIES much better to try to transform the information In terms of efﬁcacy, not much can be done in on the effect scale to a dose scale, as will be a phase I trial. These trials, mainly concerned extensively discussed in sections to come. Note that in general a respiratory drug an asthma trial we can expect to ﬁnd different must be very well tolerated to be useful, since responses. One such example is the multi-centre there are so many efﬁcacious and safe drugs on trial, in which we have many centres, often the market. Different effective in asthma or not and to estimate clini- effect sizes should not come as a surprise, cally relevant doses, the approach differs between and do not necessarily indicate interpretational the drugs that have more or less immediate problems in terms of overall effects.